An Aging Population
The population of the world is aging. It is estimated that by 2050, the percentage of the world population aged 65 years and older will almost double, increasing to 16.7% from 8.5% in 2015 (statistics from the United States Census Bureau).
Inflamm-aging is a state of chronic inflammation associated with aging. As we age, the levels of inflammatory factors increase, leading to sustained inflammatory responses and disease. Chronic inflammation is a major contributor to the acceleration of age-related diseases, such as cancer, cardiovascular disease, diabetes, neurodegenerative diseases, and mood disorders. These diseases cause a functional health decline that shorten our healthspan. At HCW, our goal is to lengthen healthspan by mitigating the effects of inflamm-aging through the dual mechanisms of modulating inflammasomes and reducing cellular senescence.
As the first line of defense to infection or tissue injury, our innate immune system activates protein complexes called inflammasomes that initiate inflammatory responses. These activated inflammasomes persist as we age, regulating the release of proinflammatory factors and are a key driver of inflamm-aging. These factors contribute to a feedback cycle of inflammasome activation and persistent inflammation in the body. Overactivation of the inflammasomes results in chronic inflammation, associated with many age-related and inflammatory diseases.
Our mission is to lengthen healthspan by modulating the inflammasome pathway to reduce inflammation and associated age-related diseases.
Cellular senescence is another contributor to inflamm-aging. Cellular senescence is a response to stress and aging, where cells stop dividing and are accompanied by a senescence-associated secretory phenotype (SASP). Considered harmful to neighboring cells, secreted SASP activates inflammasomes and drives the increasingly persistent cycle of inflammation.
As we age, senescent cells accumulate and SASP increases, leading to chronic inflammation and age-related diseases. Scientific studies have shown that reduction of senescent cells can delay, prevent, and improve age-related dysfunction.
Our proprietary immunotherapy platforms rejuvenate the immune system to reduce accumulated senescent cells and further disrupt the link between aging and chronic disease.